Well, you've lived with
your SIGNIFICANT other for some time.
The Big Bang Theory Season 10, Episode 4
it will represent a SIGNIFICANT rise
in your station.
Game of Thrones Season 5, Episode 7
...with his dating a woman
whose most SIGNIFICANT achievement...
The Big Bang Theory Season 3, Episode 11
But there's been
a SIGNIFICANT reduction
in the tumors.
Breaking Bad Season 2, Episode 10
I hear you owe that boy a SIGNIFICANT debt.
Game of Thrones Season 3, Episode 3